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JoVE Journal Medicine
In Vivo Imaging ottico dei tumori cerebrali e artrite Uso fluorescente SAPC-DOPS nanovesicles
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In Vivo Imaging ottico dei tumori cerebrali e artrite Uso fluorescente SAPC-DOPS nanovesicles

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Descriviamo un multi-angolo di rotazione imaging ottico del sistema (Maroi) in vivo quantificazione di un marcatore fluorescente consegnato da saposin C (SAPC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Impiegando modelli murini di cancro e artrite, si dimostra come l'analisi della curva Maroi segnale può essere utilizzato per la mappatura precisa e caratterizzazione biologica dei processi patologici.

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Medicina Numero 87 Saposin C (SAPC) Dioleoylphosphatidylserine (DOPS) tumore al cervello artrite fluoroforo Fluorescenza imaging ottico Multi-angolo di imaging ottico di rotazione (Maroi)
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