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I Vivo Optisk Imaging av hjernesvulster og leddgikt Bruke Fluorescent SapC-DOPS Nanovesicles

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Vi beskriver en multi-vinkel rotasjons optisk imaging (Maroi) system for in vivo kvantifisering av en fluoriserende fargestoff levert av saposin C (SapC)-dioleoylphosphatidylserine (DOPer) nanovesicles. Anvendelse av musemodeller for kreft og artritt, viser vi hvordan Maroi signalkurve-analyse kan anvendes for nøyaktig kartlegging og biologisk karakterisering av sykdomsprosessene.

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Medisin Saposin C (SapC) Dioleoylphosphatidylserine (DOPS) Brain tumor leddgikt Fluorofor fluorescens optisk bildebehandling Multi-vinkel rotasjon optisk imaging (Maroi)
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