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JoVE Journal Bioengineering
Drug-induced Sensibilisering av adenylyl cyclase
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Automated Counterflow Centrifugal System for Small-Scale Cell Processing
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Drug-induced Sensibilisering av adenylyl cyclase: Analyse Effektivisering og miniatyrisering for lite molekyl og siRNA screening programmer

Article DOI: 10.3791/51218-v • 09:39 min • January 27th, 2014
January 27th, 2014 •
1, 1, 1, 2, 1
1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company

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Vedvarende aktivering av hemmende G protein-koblede reseptorer resulterer i sensibilisering av adenylyl cyclase signalering. For å identifisere de essensielle molekylære veier, nonbiased tilnærminger er nødvendig, men denne strategi krever utviklingen av en skalerbar cellebasert assay cAMP sensibilisering. Heri, beskriver vi en allergi analysen for lite molekyl og siRNA screening.

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Bioteknologi adenylyl cyclase cAMP heterologt allergi superaktivering D2 dopamin μ opioid siRNA
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