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JoVE Journal Bioengineering
Läkemedelsinducerad Sensibilisering av adenylylcyklas
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Läkemedelsinducerad Sensibilisering av adenylylcyklas: Assay Renodling och miniatyrisering för småmolekylära och siRNA Screening Program

Article DOI: 10.3791/51218-v • 09:39 min • January 27th, 2014
January 27th, 2014 •
1, 1, 1, 2, 1
1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2Quantitative Biology, Eli Lilly and Company

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Ihållande aktivering av hämmande G-proteinkopplade receptorerna ger sensibilisering av adenylylcyklas signalering. För att identifiera de grundläggande molekylära vägar, nonbiased metoder är nödvändiga, men kräver denna strategi att utveckla en skalbar cellbaserade cAMP allergi analys. Häri beskriver vi en allergi test för små molekyler och siRNA screening.

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Bioteknik adenylylcyklas cAMP heterolog sensibilisering superactivation D2 dopamin μ opioid siRNA
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