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Journal / Immunology and Infection / Myelin Oligodendrocyte glykoprotein (MOG
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Myelin Oligodendrocyte glykoprotein (MOG
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Myelin Oligodendrocyte glykoprotein (MOG

Article DOI: 10.3791/51275-v • 08:03 min • April 15th, 2014
April 15th, 2014 •
1,2, 1, 1, 1,3
1Department of Neurology, University of Münster, 2Interdisciplinary Center for Clinical Research (IZKF), Münster, 3Institute of Physiology – Neuropathophysiology, University of Münster

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Experimentell autoimmun encefalomyelit (EAE) är en etablerad djurmodell för multipel skleros. C57BL / 6 möss immuniseras med myelin oligodendrocyte glycoprotein (MOG)-peptid 35-55 (MOG 35-55), vilket resulterar i en stigande slapp förlamning på grund av autoreaktiva immunceller i det centrala nervsystemet. Protokoll för sjukdomsinduktion och uppföljning kommer att diskuteras.

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Immunologi experimentell autoimmun encefalomyelit EAE multipel skleros MS djurmodell Autoimmunitet neuroinflammation centrala nervsystemet kikhosta
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