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En høy gjennomstrømning MHC II Binding Assay for kvantitativ analyse av peptidepitoper
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En høy gjennomstrømning MHC II Binding Assay for kvantitativ analyse av peptidepitoper

Article DOI: 10.3791/51308-v • 07:59 min • March 25th, 2014
March 25th, 2014 •
1, 2, 3, 1
1Thayer School of Engineering, Dartmouth College, 2Institute for Immunology and Informatics, University of Rhode Island, 3Department of Computer Science, Dartmouth College

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Biokjemiske analyser med rekombinant humant MHC II molekyler kan gi raske, kvantitative innsikt i immunogent epitope identifikasjon, sletting, eller design. Her blir et peptid-MHC II-bindingsanalysen skalert til 384-brønners plater som er beskrevet. Denne kostnadseffektive format bør være nyttige innen protein deimmunization og vaksine design og utvikling.

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Biokjemi Immunoassay Protein Immunogenisitet MHC II T-celle epitop høy gjennomstrømning Screen Deimmunization Vaccine Design
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