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JoVE Journal
Immunology and Infection

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在抗病毒模式识别受体RIG-I和PKR通过有限蛋白酶消化和Native PAGE监测激活
 
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在抗病毒模式识别受体RIG-I和PKR通过有限蛋白酶消化和Native PAGE监测激活

Article DOI: 10.3791/51415-v 12:43 min July 29th, 2014
July 29th, 2014

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Summary

Please note that all translations are automatically generated.

Click here for the English version.

先天防御病毒感染是由模式识别受体(模式识别受体)触发。这两个细胞质模式识别受体RIG-I和PKR结合到病毒签名的RNA,构象变化,低聚,并激活抗病毒信号。方法被描述,其允许方便地监控构象交换和这些细胞质的PRR的低聚。

Tags

传染病,第89期,先天免疫反应,病毒感染,病原体识别受体,RIG-I,PKR,IRF-3,有限蛋白酶消化,构象开关,天然PAGE,齐聚
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