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JoVE Journal Bioengineering
A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Article DOI: 10.3791/51428-v • 07:56 min • August 28th, 2014
August 28th, 2014 •
1, 1, 2, 1, 3, 1, 1,4
1Department of Plastic Surgery and Hand Surgery, University Hospital rechts der Isar, Technische Universität München, 2Institute for Signal Processing, University of Lübeck, 3Department of Plastic Surgery and Hand Surgery, University Hospital Zürich, 4FONDAP Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile

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Summary
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Vascularization is key to approaches in successful tissue engineering. Therefore, reliable technologies are required to evaluate the development of vascular networks in tissue-constructs. Here we present a simple and cost-effective method to visualize and quantify vascularization in vivo.

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Vascularization Biomaterials In Vivo Skin Defect Model Blood Vessels Transillumination Quantification Bio-artificial Scaffolds Digital Segmentation Mice Observation Time Evaluation Bilateral Wounds Artifacts High-resolution Screening Bio-activation Approaches
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