Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Intrastriatal Injection of Autologous Blood or…
JoVE Journal
Medicine

A subscription to JoVE is required to view this content.

JoVE Journal Medicine
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
Journal (Medicine)
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Journal (Medicine)
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
 

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Article DOI: 10.3791/51439-v • 09:41 min • July 3rd, 2014
July 3rd, 2014 •
1, 1, 2, 3, 1,4, 1,2,4, 1,2
1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University

Chapters

Summary
Automatic Translation

Preclinical models of intracerebral hemorrhage are utilized to mimic certain aspects of clinical disease. Thus, mechanisms of injury and potential therapeutic strategies may be explored. In this protocol, two models of intracerebral hemorrhage are described, intrastriatal (basal ganglia) injections of autologous blood or collagenase.

Tags

Intrastriatal Injection Autologous Blood Clostridial Collagenase Murine Models Intracerebral Hemorrhage Cerebrovascular Disease Morbidity Mortality Preclinical Models Pathophysiological Features Autologous Blood Injection Clostridial Collagenase Injection Brain Response Lobar Hemorrhage Small Vessel Rupture Hematoma Evolution Neuroinflammatory Response Cerebral Edema Development Neurobehavioral Outcomes Therapeutic Intervention
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter