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JoVE Journal Medicine
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Article DOI: 10.3791/51495-v • 10:31 min • December 28th, 2014
December 28th, 2014 •
1,2, 3, 4, 1, 4, 1,2, 3,4,5
1W. M. Keck Center for Transgene Research, University of Notre Dame, 2Department of Chemistry and Biochemistry, University of Notre Dame, 3Notre Dame Integrated Imaging Facility, University of Notre Dame, 4Department of Biological Sciences, University of Notre Dame, 5Harper Cancer Research Institute, University of Notre Dame

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Summary
Automatic Translation

Brain damage resulting from cerebral ischemia may be non-invasively imaged and studied in rats using pre-clinical positron emission tomography coupled with the injectable radioactive probe, 18F-fluorodeoxyglucose. Further, the use of modern software tools that include volume of interest (VOI) brain templates dramatically increase the quantitative information gleaned from these studies.

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Non-invasive Imaging Analysis Cerebral Ischemia Living Rats Positron Emission Tomography 18F-FDG Stroke Death Quality Of Life Clinical Treatment Acute Stroke Physiological Effects Brain Tissue Active Research Preclinical Model 18F-fluorodeoxyglucose PET Imaging Cerebral Rat Data X-ray Computed Tomography Albira PET-CT Instrument VOI Template Atlas Unbiased Analysis Sub-regions 3D Visualization
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