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In Vitro aggregazione Assays Utilizzando iperfosforilata Tau Protein
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In Vitro aggregazione Assays Utilizzando iperfosforilata Tau Protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Proteine ​​tau non modificate e iperfosforilata sono stati utilizzati in due metodiche di aggregazione in vitro per rivelare la cinetica di aggregazione veloce iperfosforilazione-dipendente. Questi test aprono la strada per schermi future per i composti che possono modulare la propensione di tau iperfosforilata a formare fibrille che sono alla base della progressione della malattia di Alzheimer.

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Biochimica tau Morbo di Alzheimer taupatia fosforilazione amiloide Zippers-Assisted Catalysis aggregazione proteica grovigli neurofibrillari
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