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JoVE Journal
Immunology and Infection

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Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
 

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Article DOI: 10.3791/51668-v 11:49 min June 12th, 2014
June 12th, 2014

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Summary

Human infection by Entamoeba histolytica leads to amoebiasis, a major cause of diarrhea in tropical countries. Infection is initiated by pathogen interactions with intestinal epithelial cells, provoking the opening of cell-cell contacts and consequently diarrhea, sometimes followed by liver infection. This article provides a model to assess the early host-pathogen interactions to improve our understanding of amoebiasis pathogenesis.

Tags

Entamoeba Histolytica Amoebiasis Diarrhea Hepatic Abscess Tropical Countries Intestinal Epithelial Cells Tight Junctions Disruption Intercellular Structures TJ Disassembly Molecular Mechanisms Invasion Potential Transepithelial Electrical Resistance Epithelial Surface Receptors Junctional Markers Parasite Molecules
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