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JoVE Journal Neuroscience
Olfaktoriske Neuroner opnået ved nasal biopsi Kombineret med Laser-Capture mikrodissektion
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Olfaktoriske Neuroner opnået ved nasal biopsi Kombineret med Laser-Capture mikrodissektion: En Potentiel tilgang til Uddannelse behandlingsrespons i Mental Disorders

Article DOI: 10.3791/51853-v • 08:33 min • December 4th, 2014
December 4th, 2014 •
1, 2, 1, 3, 2, 2, 4, 5, 1, 2
1Department of Psychiatry, Johns Hopkins University, 2Department of Psychiatry and Behavioral Sciences, Howard University, 3Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 4Department of Psychiatry, Sheppard Pratt Hospital, 5Department of Psychiatry, Indiana University

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I denne undersøgelse en ny platform undersøge intraneuronale molekylære underskrifter af behandlingsrespons ved bipolar sygdom (BD) blev udviklet og valideret. Lugteepitel fra BD patienter blev opnået gennem nasale biopsier. Så laser-capture mikrodissektion blev kombineret med Real Time RT-PCR til at undersøge den molekylære signatur af lithium respons i BD.

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Neuroscience bipolær lidelse lithium terapi nasal biopsi olfaktoriske epitel laser capture microdissection real-time PCR,
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