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En metode for screening og validering av Resistente Mutasjoner Against kinaseinhibitorer
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En metode for screening og validering av Resistente Mutasjoner Against kinaseinhibitorer

Article DOI: 10.3791/51984-v • 12:40 min • December 7th, 2014
December 7th, 2014 •
1, 1, 1, 1
1Divisions of Experimental Hematology and Cancer Pathology, Cancer Blood Disease Institute, Cincinnati Children's Hospital Medical Center

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Veksten av arvelig motstandskraft mot kinase hemmere utgjør betydelig utfordring for effektiv kreftbehandling. Identifisering og karakterisering av resistente mutasjoner mot en nyutviklet legemiddel hjelper i bedre klinisk ledelse og neste generasjon drug design. Her beskriver vi vår protokoll for in vitro screening og validering av resistente mutasjoner.

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Genetikk JAK2 BCR / ABL TKI tilfeldig mutagenese resistens kinaseinhibitorer,
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