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In-vitro-Test zur Methylierung Protein-Arginin-Methylierung Studieren
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In-vitro-Test zur Methylierung Protein-Arginin-Methylierung Studieren

Article DOI: 10.3791/51997-v • 10:01 min • October 5th, 2014
October 5th, 2014 •
1, 1, 1, 1, 1, 1,2, 1,3
1Department of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, 2Department of Hematology and Oncology, University of Illinois at Chicago, 3Jesse Brown Veterans Affairs Medical Center

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Protein-Arginin-Methylierung durch eine Klasse von Enzymen katalysiert viz., Protein-Arginin-Methyltransferasen (PRMTs), ist das Verfahren der enzymatischen Addition von Methyl-Gruppe (n) Arginine in Proteinen. Die in-vitro-Methylierungstest ist die zuverlässigste Werkzeug für die Beurteilung der Methylierungsstatus von bekannten oder neuen PRMT Substraten.

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Genetik PRMT Protein-Methylierung SAMe Arginin methylierte Proteine Methylierung Assay
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