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Silicium poreux microparticules pour la livraison de siRNA Therapeutics
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Silicium poreux microparticules pour la livraison de siRNA Therapeutics

Article DOI: 10.3791/52075-v • 08:31 min • January 15th, 2015
January 15th, 2015 •
*1,2, *1,3, 1, 1,4, 1, 2, 1,5, 1,6
1Department of Nanomedicine, Houston Methodist Research Institute, 2MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 3Pediatrics Department of Union Hospital, Huazhong University of Science and Technology, 4CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience & Technology of China, 5Department of Medicine, Weill Cornell Medical College, 6Department of Cell and Developmental Biology, Weill Cornell Medical College
* These authors contributed equally

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Livraison reste le principal défi pour la mise en œuvre thérapeutique de petits ARN interférents (siRNA). Ce protocole implique l'utilisation d'une plate-forme de délivrance de siRNA biocompatible et multifonctionnel, constitué par l'arginine et polyéthylènimine greffé microparticules de silicium poreux.

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Bioengineering numéro 95 le silicium poreux siRNA système NANO la thérapie du cancer transfection polycation fonctionnalisation
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