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Bioengineering

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JoVE Journal Bioengineering
En injicerbar and Drug-loaded Supramolekylær Hydrogel for Local kateter injektion i Pig Heart
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En injicerbar and Drug-loaded Supramolekylær Hydrogel for Local kateter injektion i Pig Heart

Article DOI: 10.3791/52450-v • 10:28 min • June 7th, 2015
June 7th, 2015 •
*1, *1, 2, 1, 2, 2, 2, 1
1Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, 2Department of Cardiology, Division Heart and Lungs, Interuniversity Cardiology Institute of the Netherlands (ICIN), University Medical Center Utrecht
* These authors contributed equally

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Supramolekylære hydrogelators baseret på ureidogrupper-pyrimidinoner tillader fuld kontrol over de makroskopiske gel egenskaber og sol-gel switching adfærd ved hjælp af pH. Her præsenterer vi en protokol for at formulere og injektion sådan supramolekylær hydrogelator via et kateter leveringssystem for lokal levering direkte i relevante områder i grisen hjerte.

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Bioengineering supramolekylære polymerer hydrogeler kateter injektion drug delivery pH for skift gris model
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