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Journal / Immunology and Infection / Gebruik makend van de Antigen…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Gebruik makend van de Antigen Capsid-Incorporation strategie voor de ontwikkeling van adenovirus serotype 5-Vectored Vaccin Approaches
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Gebruik makend van de Antigen Capsid-Incorporation strategie voor de ontwikkeling van adenovirus serotype 5-Vectored Vaccin Approaches

Article DOI: 10.3791/52655-v • 13:36 min • May 6th, 2015
May 6th, 2015 •
1, 1, 1, 1,2
1Department of Medicine, University of Alabama at Birmingham, 2Center for AIDS Research, University of Alabama at Birmingham

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Hier presenteren we een protocol om een proof-of-principle bivalente adenovirus type 5 (Ad5) vector genereren Ad5 / H5-HVR1-KWAS-HVR5-His 6 door gebruik te maken van de Antigen Capsid-Incorporation strategie. Deze vector werd aangetoond kwalitatieve conditie vertonen het vermogen om Ad5-positieve sera in vitro, en de antigeniteit en immunogeniteit ontsnappen naar de opgenomen antigenen.

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Immunologie Antigen Capsid-Incorporation strategie transgene methode adenovirus (Ad) vaccin capsideproteïnen dual modificatie reeds bestaande immuniteit (PEI)
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