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视网膜胶质细胞活化的体内动力学在神经退行性疾病:共聚焦成像眼底及细胞形态计量小鼠青光眼
 
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视网膜胶质细胞活化的体内动力学在神经退行性疾病:共聚焦成像眼底及细胞形态计量小鼠青光眼

Article DOI: 10.3791/52731-v 12:48 min May 11th, 2015
May 11th, 2015

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Summary

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Click here for the English version.

小胶质细胞活化和小神经胶质细胞是关键应对慢性神经退行性病变。这里,我们提出在体内 ,视网膜CX3CR1-GFP +胶质细胞共聚焦检眼镜的长期可视化方法,以及用于阈和形态分析,以确定和量化它们的活化。我们监测期间与年龄有关的青光眼的早期阶段小胶质细胞的变化。

Tags

医学,第99,神经科学,小胶质细胞,神经变性,青光眼,视网膜,视神经头,共焦扫描激光检眼镜,实时图像分析,分割由阈值,细胞形态CX3CR1,DBA / 2J
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