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In vivo Dynamics of Retinal mikrogliaceller Aktivering Under Neurodegeneration
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In vivo Dynamics of Retinal mikrogliaceller Aktivering Under Neurodegeneration: Konfokal oftalmoskopiske Imaging og Cell Morfometri i Mouse Glaukom

Article DOI: 10.3791/52731-v • 12:48 min • May 11th, 2015
May 11th, 2015 •
1, 1, 2, 1
1Department of Neurobiology & Anatomy, University of Utah, 2Department of Ophthalmology & Visual Sciences, University of Utah

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Mikroglia aktivering og mikrogliose er centrale reaktioner på kronisk neurodegeneration. Her præsenterer vi metoder til in vivo, langsigtet visualisering af retinale CX3CR1-GFP + mikrogliaceller celler ved konfokal oftalmoskopi og til grænsen og morfometrisk analyser at identificere og kvantificere deres aktivering. Vi overvåger mikrogliaceller ændringer i løbet tidlige stadier af aldersrelateret glaukom.

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Medicin Neuroscience mikroglia neurodegeneration grøn stær nethinde synsnerven konfokal scanning laser oftalmoskopi live billedanalyse segmentering af tærskling celle morfometri CX3CR1 DBA / 2J
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