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JoVE Journal Bioengineering
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
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Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

Article DOI: 10.3791/52797-v • 10:32 min • March 26th, 2015
March 26th, 2015 •
1, 1, 1, 2, 2, 1, 1
1Department of Orthopaedic Surgery, University of California Los Angeles, 2Department of Bioengineering, University of California Los Angeles

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Animal models are important tools for the evaluation of tissue-engineered grafts. This paper presents the protocol for preparing an electrospun biodegradable polymer graft for use in anterior cruciate ligament tissue engineering, as well as a surgical protocol for implantation in a rat model.

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Athymic Rat Model Evaluation Engineered Anterior Cruciate Ligament (ACL) Grafts ACL Rupture Surgery Ligament Reconstruction Autograft Allograft Tissue-engineered Graft Electrospun Polymer Graft Polycaprolactone Graft Biocompatible Biodegradable Porous Aligned Fibers Animal Model Intra-articular Athymic Rat Model Xenogeneic Cells Histology Biomechanical Testing Regenerative Medicine Approach Treatment Of ACL Rupture
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