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Neuroscience

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Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
 

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Article DOI: 10.3791/52831-v 13:58 min July 29th, 2015
July 29th, 2015

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Summary

Generation of induced pluripotent stem cells provides fascinating prospects for the derivation of autologous transplants. However, progression through a pluripotent state and laborious re-differentiation still hinders clinical translation. Here we describe the derivation of adult human fibroblasts and their direct conversion into induced neural progenitor cells and the subsequent differentiation into neural lineages.

Tags

Adult Human Fibroblasts Neural Progenitor Cells Induced Pluripotent Stem Cells Somatic Cells Autologous Transplants Histocompatibility Barriers Neoplastic Potential Genomic Instability Direct Conversion Induced Neural Progenitor Cells Cell Replacement Disease Modeling Drug Screening Oct4 Sox2 Klf4 C-Myc
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