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Bioengineering

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JoVE Journal Bioengineering
In vitro model af fysiologiske og patologiske Blood Flow med Application til Undersøgelser af vaskulær Cell Remodeling
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In vitro model af fysiologiske og patologiske Blood Flow med Application til Undersøgelser af vaskulær Cell Remodeling

Article DOI: 10.3791/53224-v • 07:30 min • November 3rd, 2015
November 3rd, 2015 •
1, 2, 1
1Department of Mechanical Engineering, University of Colorado at Boulder, 2Product Development, Covidien, Ltd.

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Denne protokol replikater fysiologisk eller patologisk blodgennemstrømning in vitro for at hjælpe med at bestemme celle-respons ved sygdomstilstande patologier. Ved at indføre et tryk dæmpekammer nedstrøms for en blod pumpe, kan blodgennemstrømningen tværs vaskulaturen blive sammenfattet og pålægges et monolag af vaskulær endotel eller en mimetisk co-kultur.

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Bioengineering vaskulær lidelse Mechanotransduction pulsatility Index Arteriel lygteopstilling endotelceller glatte muskelceller Fluid Shear Vaskulær Remodeling
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