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JoVE Journal Chemistry
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Article DOI: 10.3791/53760-v • 07:53 min • April 26th, 2016
April 26th, 2016 •
1, 1
1Institute of Environment, Health, Risks and Futures, Cranfield University

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The most commonly used method for nanostructured lipid carrier (NLC) synthesis involves oil-in-water emulsion, homogenization and solidification. This was modified here by applying high shear dispersion after solidification to achieve a NLC with desirable size, improved drug encapsulation and drug loading efficiency as a potential carrier for dacarbazine delivery.

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Encapsulation Cancer Therapeutic Agent Dacarbazine Nanostructured Lipid Carrier Formulation Drug Dispersity Aqueous Solution Historic Stability Drug-release Control Half-life Acetone Ethanol Glyceryl Palmitosterate Isopropyl Myristate D-a-tocopheryl Polyethylene Glycol Succinate Soybean Lecithin Water Bath Poloxamer 188 Emulsion Organic Solvent Fridge Four Degrees Celsius Solidify NLCs Homogenizer
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