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Methods for Acute and Subacute Murine Hindlimb Ischemia
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Methods for Acute and Subacute Murine Hindlimb Ischemia

Article DOI: 10.3791/54166-v • 07:57 min • June 21st, 2016
June 21st, 2016 •
1, 1, 1, 1
1Division of Cardiology, Department of Medicine, Duke University Medical Center

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Summary
Automatic Translation

Surgical induction of hindlimb ischemia in the mouse is useful to examine angiogenesis, however this is compromised in certain inbred mouse strains that display marked ischemia-induced tissue necrosis. Methods are described to induce subacute limb ischemia using ameroid constrictors to circumvent this problem through the induction of gradual arterial occlusion.

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Acute Hindlimb Ischemia Subacute Hindlimb Ischemia Peripheral Artery Disease Mouse Femoral Artery Sutures Ameroid Constrictors Animal Models Limb Ischemia Control Sedation Hair Removal Surgical Procedure Dissection Microscope Surgical Tape Povidone
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