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JoVE Journal Bioengineering
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In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules

Article DOI: 10.3791/54279-v • 11:13 min • August 22nd, 2016
August 22nd, 2016 •
1, 1, 1, 2, 1, 1
1Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Università di Milano, 2Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca

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Summary
Automatic Translation

A method to establish an in vitro model of blood-brain barrier based on a co-culture of rat brain microvascular endothelial cells and astrocytes is described and validated. This system proved to be a valid tool to study the effect of nanoformulation on the trans-barrier permeation of fluorescent molecules.

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In Vitro Permeation FITC-loaded Ferritins Rat Blood-brain Barrier Nanoformulated Molecules Drug Delivery Resistance Of Central Level System Disease Pharmacological Therapies Low Permeation Of Drugs BBB Permeation Encapsulated Molecules Single BBB Model Neurological Disorders High Selectivity Of The Blood Brain Barrier Ferritin Nano Cages Drug Delivery System FITC Carrageenan Molecules Organic Nano Particles Inorganic Nano Particles Cell Culture Flasks Poly L Lysine Rat Cortical Astrocytes Fibronectin
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