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Journal / Biochemistry / 方法确定HCN1和TRIP8b之间蛋白 -…
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Biochemistry

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JoVE Journal Biochemistry
方法确定HCN1和TRIP8b之间蛋白 - 蛋白相互作用的小分子抑制剂
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方法确定HCN1和TRIP8b之间蛋白 - 蛋白相互作用的小分子抑制剂

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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HCN通道和其辅助亚基之间的相互作用已被确定为在抑郁症的治疗靶点。这里，用于识别这种蛋白质 - 蛋白质相互作用的小分子抑制剂荧光基于偏振的方法，提出。

Tags

生物化学，第117，高通量筛选，药物发现，蛋白质 - 蛋白质相互作用，荧光偏振，HCN TRIP8b
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