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Journal / Biochemistry / Metodo per identificare piccole molecole…
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Biochemistry

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JoVE Journal Biochemistry
Metodo per identificare piccole molecole inibitori della interazione proteina-proteina tra HCN1 e TRIP8b
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Metodo per identificare piccole molecole inibitori della interazione proteina-proteina tra HCN1 e TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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L'interazione tra i canali HCN e la loro subunità accessoria è stato identificato come un obiettivo terapeutico nel Disturbo Depressivo Maggiore. Qui, un metodo di polarizzazione basato fluorescenza per identificare piccole molecole inibitrici di questa interazione proteina-proteina, è presentato.

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Biochimica lo screening ad alto rendimento scoperta di nuovi farmaci le interazioni proteina-proteina fluorescenza polarizzata HCN TRIP8b
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