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Journal / Biochemistry / HCN1とTRIP8bの間のタンパク質 -…
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Biochemistry

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JoVE Journal Biochemistry
HCN1とTRIP8bの間のタンパク質 - タンパク質相互作用の小分子阻害剤を同定するための方法
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HCN1とTRIP8bの間のタンパク質 - タンパク質相互作用の小分子阻害剤を同定するための方法

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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HCNチャネルとそれらの補助サブユニット間の相互作用は、大うつ病性障害における治療標的として同定されています。ここで、このタンパク質 - タンパク質相互作用の小分子阻害剤を同定するための蛍光偏光ベースの方法が提供されます。

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生化学号117、ハイスループットスクリーニング、薬物発見、タンパク質 - タンパク質相互作用を、蛍光偏光、HCN、TRIP8b
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