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A High Throughput, Multiplexer e mirata Proteomica CSF test per quantificare neurodegenerative Biomarkers e apolipoproteina E Isoforme Stato
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A High Throughput, Multiplexer e mirata Proteomica CSF test per quantificare neurodegenerative Biomarkers e apolipoproteina E Isoforme Stato

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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Descriviamo un alto rendimento, multiplex, e il dosaggio mirato liquido cerebrospinale proteomica (CSF) sviluppata con un potenziale per la traduzione clinica. Il test può quantificare potenziali marcatori e fattori di rischio per la neurodegenerazione, come le varianti apolipoproteina E (E2, E3 e E4), e misurarne l'espressione allelica.

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Medicina CSF proteomica mirati multipla di monitoraggio di reazione apolipoproteina E isoforma la demenza biomarker spettrometria di massa tandem multiplex
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