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En hög genomströmning, Multiplex och riktade proteomik CSF analys för att kvantifiera neurodegenerativa Biomarkers och apolipoprotein E isoformer Status
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En hög genomströmning, Multiplex och riktade proteomik CSF analys för att kvantifiera neurodegenerativa Biomarkers och apolipoprotein E isoformer Status

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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Vi beskriver en hög genomströmning, multiplex, och riktade proteomik cerebrospinalvätska (CSF) analys utvecklad med potential för klinisk översättning. Testet kan kvantifiera potentiella markörer och riskfaktorer för neurodegeneration, såsom apolipoprotein E varianterna (E2, E3 och E4), och mäta deras alleliska uttryck.

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Medicin CSF riktade proteomik Multiple Reaction Monitoring apolipoprotein E isoform demens biomarkör tandemmasspektrometri multiplex
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