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JoVE Journal Chemistry
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Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Journal (Chemistry)
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Employing Pressurized Hot Water Extraction (PHWE) to Explore Natural Products Chemistry in the Undergraduate Laboratory
Journal (Chemistry)
Employing Pressurized Hot Water Extraction (PHWE) to Explore Natural Products Chemistry in the Undergraduate Laboratory
 
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Article DOI: 10.3791/54776-v • 11:27 min • December 4th, 2016
December 4th, 2016 •
1, 1, 1, 1
1MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics

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Detta protokoll beskriver framställningen och karakteriseringen av en dendrimer magnetisk resonanstomografi (MRT) kontrastmedel som bär cyklen-baserade makrocykliska kelater samordnande paramagnetiska gadolinium-joner. I en serie av MRI-experiment in vitro, producerade detta medel en förstärkt MRI signal jämfört med den kommersiellt tillgängliga monomera analogen.

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Kemi Chelates kontrastmedel dendrimer gadolinium organisk syntes magnetisk resonanstomografi nanomaterial
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