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JoVE Journal Neuroscience
A Free-breathing fMRI Method to Study Human Olfactory Function
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A Free-breathing fMRI Method to Study Human Olfactory Function

Article DOI: 10.3791/54898-v • 10:42 min • July 30th, 2017
July 30th, 2017 •
1, 1, 1, 1, 1, 1, 1, 1,2
1Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, 2Department of Neurosurgery, Pennsylvania State University College of Medicine

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We present the technical challenges and solutions for obtaining reliable functional magnetic resonance imaging (fMRI) data from the human central olfactory system. This includes special considerations in olfactory fMRI paradigm design, descriptions of fMRI data acquisition with an MRI-compatible olfactometer, odorant selection, and a special software tool for data post-processing.

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Free-breathing FMRI Study Human Olfactory Function Method Efficient Easily Adaptable Mapping Olfactory System Interference Natural Breathing Obstacle Olfactory FMRI Brain Activation Odor Stimulation Inconsistency Repetitive Odor Stimulation Asynchrony Respiration Odor Delivery Solution Respiration-triggered Olfactory FMRI Paradigm Data Collection Event-related Resist Habituation Inconsistent Inhalation Patterns Odorants Minimize Trigeminal Stimulation Habituation Effects MRI Environment Olfactometer Assembly Respiration-triggered Paradigm Data Processing Program ONSET
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