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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear
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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Article DOI: 10.3791/54951-v • 09:18 min • March 8th, 2017
March 8th, 2017 •
*1,2,3, *1, 1,2,4, 1,2, 3,5, 1,2,3, 1,2,4
1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria, Universidad Complutense de Madrid, 5Departmento de Otorrino laringología, Hospital Universitario La Paz
* These authors contributed equally

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Summary
Automatic Translation

Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.

Tags

Drug Delivery Methods Mouse Inner Ear Bullostomy Transtympanic Injection Hearing Parameters Cochlear Cytoarchitecture Markers Minimally Invasive Therapy Of Hearing Loss Microsurgical Procedures Anatomical Knowledge Surgical Training Mono-aural Responses Anesthesia Subdermal Needle Electrode Reference Electrode Ground Electrode Electrical Impedance
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