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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Article DOI: 10.3791/55085-v • 07:43 min • February 8th, 2017
February 8th, 2017 •
1, 1, 1
1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center

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Summary
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Brain metastasis has become an urgent unmet medical need as its incidence has increased while therapeutic options have remained palliative. Creating experimental animal models of brain metastasis via intracarotid arterial injection of cancer cells facilitates mechanistic studies of the disease biology and evaluation of novel intervention regimens.

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Intracarotid Cancer Cell Injection Mouse Models Brain Metastasis In Vivo Experimental Models Therapeutic Efficacy High Reproducibility Low Variability Microsurgical Injection Carotid Artery Cancer Cells DMEM F12 Media Serum-free Media Trypsin FBS-containing Media Centrifugation
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