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Immunology and Infection

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JoVE Journal Immunology and Infection
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Article DOI: 10.3791/55273-v • 09:57 min • April 5th, 2017
April 5th, 2017 •
1, 1
1Department of Medicine, University of British Columbia

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Summary
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We have developed a modular high-throughput screening system for discovering novel compounds against Mycobacterium tuberculosis, targeting intracellular and in-broth growing bacteria as well as cytotoxicity against the mammalian host cell.

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Efficacy Screening Cytotoxicity Screening Inhibitors Intracellular Mycobacterium Tuberculosis Luciferase-based Assay TB Drug Development CFU Assay Manual Pipetting Automation Consistent Pipetting Technique THP1 Cells RPMI Medium OD600 Measurement Bacterial Density Opsonization
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