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Uttryck av exogen cytokin i patient-härledda xenotransplantat via injektion med en cytokin-transducerad ströcellinje
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Uttryck av exogen cytokin i patient-härledda xenotransplantat via injektion med en cytokin-transducerad ströcellinje

Article DOI: 10.3791/55384-v • 12:58 min • May 10th, 2017
May 10th, 2017 •
1, 1, 1, 2, 3, 1, 1, 1
1Department of Pathology and Human Anatomy, Loma Linda University, 2Department of Basic Sciences, Loma Linda University, 3Department of Medicine, Loma Linda University

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Beskriven här är en metod för att producera exogent cytokin i patient-härledda xenograftmus (PDX) via veckovis intraperitoneal injektion av en cytokin-transducerad stromalcellinje. Denna metod breddar nyttan av PDX och ger möjlighet till övergående eller långvarig exogen cytokinleverans i en mängd PDX-modeller.

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Medicin Utgåva 123 Xenograft preklinisk modell leukemi patient-härledda xenotransplantat (PDX), tymisk stromal lymfopoietin (TSLP)
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