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JoVE Journal Bioengineering
Automatiseret Sammentrækning Analyse af humant Engineered Heart Væv til Cardiac Drug Safety Screening
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Automatiseret Sammentrækning Analyse af humant Engineered Heart Væv til Cardiac Drug Safety Screening

Article DOI: 10.3791/55461-v • 10:39 min • April 15th, 2017
April 15th, 2017 •
1, 1, 1, 1, 1, 1, 1
1Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

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Her viser vi genereringen af ​​human manipuleret hjertevæv fra inducerede pluripotente stamceller (hiPSC) afledt cardiomyocytter. Vi præsenterer en metode til at analysere kontraktionskraft og eksemplarisk ændring af sammentrækning mønster af hERG kanal inhibitor E-4031. Denne metode viser høj grad af robusthed og egnethed til hjerte- lægemiddelscreening.

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Bioengineering Engineered hjertevæv cardiomyocytter vævsmanipulering hjertedifferentiering lægemiddelsikkerhed farmakologi
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