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Immunology and Infection

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JoVE Journal Immunology and Infection
Een IL-8 Transiently Transgenized Mouse Model voor de
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Een IL-8 Transiently Transgenized Mouse Model voor de

Article DOI: 10.3791/55499-v • 08:16 min • July 7th, 2017
July 7th, 2017 •
*1, *2, *3, 3, 4, 5,2, 6, 7, 2, 8, 1
1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona
* These authors contributed equally

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De hier beschreven werkwijze maakt het mogelijk om visualisatie van IL-8 promotorafhankelijke ontstekingsactivering in de longen van muizen door middel van niet-invasieve bioluminescentie beeldvorming (BLI). Het zelfde dier kan meerdere keren tot BLI worden onderworpen tot maximaal twee maanden vanaf de tijd van afgifte van het luciferase reporterconstruct.

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Immunologie Uitgave 125 Inflammatie Genlevering, bioluminescentie beeldvorming interleukine-8 long
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