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Journal / Immunology and Infection / Bir IL-8 Geçici Transgenize Edilmiş Fare Modeli
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Immunology and Infection

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JoVE Journal Immunology and Infection
Bir IL-8 Geçici Transgenize Edilmiş Fare Modeli
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Bir IL-8 Geçici Transgenize Edilmiş Fare Modeli

Article DOI: 10.3791/55499-v • 08:16 min • July 7th, 2017
July 7th, 2017 •
*1, *2, *3, 3, 4, 5,2, 6, 7, 2, 8, 1
1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona
* These authors contributed equally

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Burada açıklanan yöntem, non-invaziv biyolüminesans görüntüleme (BLI) yoluyla farelerin akciğerlerinde IL-8 promotöre bağlı inflamasyon aktivasyonunun görselleştirilmesine olanak tanır. Aynı hayvan lusiferaz muhabiri yapısının teslim edildiği andan itibaren iki aya kadar birden fazla kez BLI'ye tabi tutulabilir.

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İmmunoloji Sayı 125 İnflamasyon gen aktarımı, biyolüminesans görüntüleme interlökin-8 akciğer
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