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Journal / Immunology and Infection / In vitro- metoder til sammenligning af målbinding …
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Immunology and Infection

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JoVE Journal Immunology and Infection
In vitro- metoder til sammenligning af målbinding og CDC-induktion mellem terapeutiske antistoffer
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In vitro- metoder til sammenligning af målbinding og CDC-induktion mellem terapeutiske antistoffer: applikationer i biosimilaritetsanalyse

Article DOI: 10.3791/55542-v • 07:25 min • May 4th, 2017
May 4th, 2017 •
1,2, 1, 3, 4,5, 6
1Unit for Development and Research in Bioprocesses Unit (UDIBI), National School of Biological Sciences, National Polytechnic Institute (IPN), University of Mexico (UNAM), 2School of Chemistry, National Autonomous University of Mexico (UNAM), 3Graduate Program in Chemical Sciences, National Autonomous University of Mexico (UNAM), 4Unit for Development Research and Medical Innovation in Biotechnology (UDIMEB), National School of Biological Sciences, National Polytechnic Institute (IPN), 5Department of Immunology, National Scool of Biological Sciences, National Polytechnic Institute (IPN), 6Department of Pharmacology and Unit of Translational Biomedicine (CMN 20 de noviembre), School of Medicine, National Autonomous University of Mexico (UNAM)

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Denne protokol beskriver in vitro sammenligning af to centrale funktionelle egenskaber af rituximab: targetbindende og komplement-afhængig cytotoksicitet (CDC) induktion. Metoderne blev anvendt til en side-til-side sammenligning mellem henvisning rituximab og en rituximab biosimilært. Disse assays kan anvendes under biosimilar udvikling eller som en kvalitetskontrol i deres produktion.

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Immunologi udgave 123 Rituximab biosimilar anti-CD20 terapeutisk mAb CDC flowcytometri Daudi-celler
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