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Neuroscience

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JoVE Journal Neuroscience
Anatomisk inspirerte tredimensjonale mikrovev-konstruerte nevrale nettverk for nervesystemet Rekonstruksjon, modulering og modellering
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Anatomisk inspirerte tredimensjonale mikrovev-konstruerte nevrale nettverk for nervesystemet Rekonstruksjon, modulering og modellering

Article DOI: 10.3791/55609-v • 10:45 min • May 31st, 2017
May 31st, 2017 •
*1,2,3, *1,2,3, 1,2,3, 2,3, 2,3, 2,3,4, 2,3, 2,3, 2,3
1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 2Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 4School of Biomedical Engineering, Drexel University
* These authors contributed equally

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Dette manuskriptet beskriver fremstillingen av mikrovev-manipulerte nevrale nettverk: tredimensjonale mikronstørrelses konstruksjoner bestående av langjusterte aksonale kanaler som spenner over aggregerte nevronpopulasjoner som er innkapslet i en rørformet hydrogel. Disse levende stillasene kan fungere som funksjonelle reléer for å rekonstruere eller modulere nevrale kretser eller som biofideliske test-senger som etterligner grå-hvitt materie-neuroanatomi.

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Neurovitenskap utgave 123 Neural vevsteknikk biomaterialer levende stillaser neurotrauma neuroregenerasjon neuromodulering aksonale veier synapser
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