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JoVE Journal Neuroscience
Redes neuronais modificadas por micro-tecidos tridimensionais com inspiração anatômica para a reconstrução, modulação e modelagem do sistema nervoso
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Redes neuronais modificadas por micro-tecidos tridimensionais com inspiração anatômica para a reconstrução, modulação e modelagem do sistema nervoso

Article DOI: 10.3791/55609-v • 10:45 min • May 31st, 2017
May 31st, 2017 •
*1,2,3, *1,2,3, 1,2,3, 2,3, 2,3, 2,3,4, 2,3, 2,3, 2,3
1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 2Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 4School of Biomedical Engineering, Drexel University
* These authors contributed equally

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Este manuscrito detalha a fabricação de redes neurais manipuladas com micro-tecidos: construções tridimensionais de tamanho micrométrico, constituídas por longos trilhos axonais alinhados que abrangem a (s) população (s) neuronal agregada (s) envolvida (s) em um hidrogel tubular. Esses andaimes vivos podem servir como relés funcionais para reconstruir ou modular circuitos neurais ou como bancas biofidais que imitam a neuroanatomia de matéria cinza-branca.

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Neurociência Edição 123 Engenharia de tecidos neurais biomateriais andaimes vivos neurotrauma neuroregeneração neuromodulação vias axonais sinapses
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