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Journal / Developmental Biology / Protokol for differentieringen af ​​humane…
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Developmental Biology

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JoVE Journal Developmental Biology
Protokol for differentieringen af ​​humane inducerede pluripotente stamceller i blandede kulturer af neuroner og glia til neurotoksicitetstestning
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Protokol for differentieringen af ​​humane inducerede pluripotente stamceller i blandede kulturer af neuroner og glia til neurotoksicitetstestning

Article DOI: 10.3791/55702-v • 09:02 min • June 9th, 2017
June 9th, 2017 •
1, 1, 1, 1
1Directorate F - Health, Consumers and Reference Materials, Joint Research Centre

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Humant inducerede pluripotente stamceller (hiPSC'er) betragtes som et stærkt værktøj til lægemiddel- og kemisk screening og til udvikling af nye in vitro- modeller til toksicitetstestning, herunder neurotoksicitet. Her beskrives en detaljeret protokol for differentieringen af ​​hiPSC'er i neuroner og glia.

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Udviklingsbiologi udgave 124 humant induceret pluripotente stamceller differentiering neuroner glia neurotoksicitet Nrf2-pathway aktivering
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