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Journal / Bioengineering / Drie-dimensionale weefsel ontworpen uitgelijnd…
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Bioengineering

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JoVE Journal Bioengineering
Drie-dimensionale weefsel ontworpen uitgelijnd Astrocyt netwerken vergemakkelijken zenuwstelsel regeneratie te recapituleren Developmental mechanismen
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Drie-dimensionale weefsel ontworpen uitgelijnd Astrocyt netwerken vergemakkelijken zenuwstelsel regeneratie te recapituleren Developmental mechanismen

Article DOI: 10.3791/55848-v • 08:56 min • January 10th, 2018
January 10th, 2018 •
*1,2,3, *1,2,4, 1,2,4, 1,2, 1,5, 1,5, 1,2,4, 1,2,5
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 2Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 3School of Biomedical Engineering, Drexel University, 4Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania
* These authors contributed equally

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Wij demonstreren de ontwikkeling van zelf geassembleerde, driedimensionale bundels van lengterichting uitgelijnde astrocytic waarin en processen binnen het omhulsel van een roman biomaterial. Deze "levende steigers", het tentoonstellen van micron-schaal diameter nog uitbreiding centimeter lengte, kan dienen als proefnetwerken neurologische mechanismen bestuderen of vergemakkelijken van neuroregeneration door leiding neuronale migratie en/of axonale ontworpen vastloper.

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Bioengineering kwestie 131 zenuwweefsel engineering levende steigers neurotrauma neuroregeneration cel migratie axon vastloper Astrocyt netwerken neurale stamcellen
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