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Journal / Cancer Research / Oprettelse af dobbelt modstand mod EGFR-TKI og…
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JoVE Journal Cancer Research
Oprettelse af dobbelt modstand mod EGFR-TKI og MØDTE TKI i lunge adenocarcinom celler In Vitro med en 2-trins dosis-eskalering Procedure
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Oprettelse af dobbelt modstand mod EGFR-TKI og MØDTE TKI i lunge adenocarcinom celler In Vitro med en 2-trins dosis-eskalering Procedure

Article DOI: 10.3791/55967-v • 09:38 min • August 11th, 2017
August 11th, 2017 •
1, 1, 1,2, 1
1Institute of Molecular Oncology, Showa University, 2Center for Biotechnology, Showa University

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En in vitro- metode til fastlæggelse af dobbelt modstand mod en EGFR-TKI og en MET-TKI i kræftceller er beskrevet. Denne metode er nyttig for at udvikle behandlinger til patienter med EGFR-mutationer, som udviser sygdomsprogression trods EGFR-TKI behandling med MET-forstærkning. Det kan også ændres for hæmmere rettet mod andre molekyler.

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Kræftforskning sag 126 lungekræft erhvervet dual-modstand EGFR-TKI MET-TKI Lungeceller adenocarcinom PC-9 trinvis dosis eskalering
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