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JoVE Journal Medicine
Optimeret LC-MS/MS metoden til høj overførselshastighed analyse af kliniske prøver af Ivacaftor, dets vigtigste metabolitter, og Lumacaftor i biologiske væsker af cystisk fibrose patienter
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Optimeret LC-MS/MS metoden til høj overførselshastighed analyse af kliniske prøver af Ivacaftor, dets vigtigste metabolitter, og Lumacaftor i biologiske væsker af cystisk fibrose patienter

Article DOI: 10.3791/56084-v • 06:14 min • October 15th, 2017
October 15th, 2017 •
1, 1, 1,2, 1
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 2Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University

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Kombination af Ivacaftor og ivacaftor-lumacaftor er to nye CF narkotika. Men der er stadig en mangel på forståelse på deres PK/PD og farmakologi. Vi præsenterer en optimeret HPLC-MS teknik til simultan analyse af ivacaftor og dets vigtigste metabolitter, og lumacaftor.

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Medicin spørgsmål 128 Ivacaftor lumacaftor HPLC-MS cystisk fibrose plasma spyt biologiske væsker
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