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Journal / Immunology and Infection / Induktion af lammelse og visuelle System skade i…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Induktion af lammelse og visuelle System skade i mus af T celler specifik for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induktion af lammelse og visuelle System skade i mus af T celler specifik for Neuromyelitis Optica Autoantigen Aquaporin-4

Article DOI: 10.3791/56185-v • 09:29 min • August 21st, 2017
August 21st, 2017 •
*1,2, *1, 1,2, 3, 3, 1, 4, 1,2
1Department of Neurology, University of California, 2Program in Immunology, University of California, 3Department of Neurology and Neurological Sciences, Stanford University, 4Department of Pathology, Stanford University
* These authors contributed equally

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Vi præsenterer her, en protokol for at fremkalde lammelser og opticospinal betændelse af overførsel af aquaporin-4 (AQP4)-specifikke T-celler fra AQP4- / - mus til WT mus. Derudover viser vi hvordan serie optisk kohærens tomografi til at overvåge visuelle system dysfunktion.

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Immunologi sag 126 neuromyelitis optica aquaporin-4 flow flowcytometri T-celle adoptiv overførsel CNS autoimmunitet optisk kohærens tomografi
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