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JoVE Journal Neuroscience
Vurdering af blod - hjerne barrieren permeabilitet af intravenøs Infusion af FITC-mærket Albumin i en musemodel af neurodegenerativ sygdom
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Vurdering af blod - hjerne barrieren permeabilitet af intravenøs Infusion af FITC-mærket Albumin i en musemodel af neurodegenerativ sygdom

Article DOI: 10.3791/56389-v • 07:22 min • November 8th, 2017
November 8th, 2017 •
1, 1, 1, 1, 1
1Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed

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I denne undersøgelse præsenterer vi en let og effektiv procedure til evaluering af forstyrrelser af blod - hjerne barrieren neurodegenerative betingelser. For at nå vores mål, vi infunderes høj molekylvægt fluorescein isothiocyanat mærket (FITC)-albumin i mus jugularis vene og vurderet dets lækage i hjernen parenkym af Fluorescens mikroskopi.

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Neurovidenskab sag 129 blod - hjerne barrieren (BBB) BBB permeabilitet FITC-albumin neurodegeneration intravenøs injektion musen model
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