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Studera hypotalamus Insulin signalen till perifera glukosintolerans med en kontinuerlig drog infusionssystemet in i musen hjärnan
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Studera hypotalamus Insulin signalen till perifera glukosintolerans med en kontinuerlig drog infusionssystemet in i musen hjärnan

Article DOI: 10.3791/56410-v • 08:32 min • January 4th, 2018
January 4th, 2018 •
1,2, 1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University

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Detta protokoll studier chemokine (C-C motiv) ligand 5 (CCL5) i hypotalamus roll genom att leverera en antagonist, MetCCL5, in i musen hjärnan använder ett mikro-osmotic pumpsystem hjärnan infusion. Detta övergående hämning av CCL5 verksamhet avbryts hypotalamus insulin signalering, vilket leder till glukosintolerans och perifera systemiska insulinkänslighet.

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Medicin fråga 131 hjärnan drug delivery mikro-osmotic pump insulinresistens glukosmetabolism chemokine (C-C motiv) ligand 5 (CCL5) diabetes mellitus typ 2 (T2DM)
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